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Neuropsychological Rehabilitation
An International Journal
Volume 32, 2022 - Issue 1
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Articles

Intensive aphasia therapy improves low mood in fluent post-stroke aphasia: Evidence from a case-controlled study

Marcelo L. Berthiera Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico–Sanitarias (CIMES), University of Malaga, Málaga, Spain;b Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech and Language Therapy, University of Malaga, Málaga, Spain;c Instituto de Investigación Biomédica de Málaga – IBIMA, Málaga, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6393-3487View further author information
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Lisa Edelkrauta Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico–Sanitarias (CIMES), University of Malaga, Málaga, Spain;b Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech and Language Therapy, University of Malaga, Málaga, Spain;c Instituto de Investigación Biomédica de Málaga – IBIMA, Málaga, Spain;d Department of Psychobiology and Methodology of Behavioral Sciences, Faculty of Psychology and Speech and Language Therapy, University of Málaga, Málaga, SpainORCID Iconhttps://orcid.org/0000-0001-7444-2686View further author information
ORCID Icon,
Bettina Mohre Department of Psychiatry, Charité Universitätsmedizin, Berlin, Germany;f Zentrum für Neuropsychologie und Intensive Sprachtherapie, ZENIS, Berlin, GermanyView further author information
,
Friedemann Pulvermüllerg Brain Language Laboratory, Department of Philosophy and Humanities, WE4, Freie Universität Berlin, Berlin, Germany;h Berlin School of Mind and Brain, Humboldt Universität zu Berlin, Berlin, GermanyView further author information
,
Sergio E. Starksteini Division of Psychiatry, School of Medicine, The University of Western Australia, Perth, AustraliaView further author information
,
Cristina Green-Herediaj Service of Neuropsychology, Hospital Quirón, Malaga, SpainView further author information
&
Guadalupe Dávilaa Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico–Sanitarias (CIMES), University of Malaga, Málaga, Spain;b Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech and Language Therapy, University of Malaga, Málaga, Spain;c Instituto de Investigación Biomédica de Málaga – IBIMA, Málaga, Spain;d Department of Psychobiology and Methodology of Behavioral Sciences, Faculty of Psychology and Speech and Language Therapy, University of Málaga, Málaga, SpainView further author information
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Pages 148-163 | Received 12 Feb 2020, Accepted 08 Aug 2020, Published online: 31 Aug 2020
 
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ABSTRACT

Introduction: Depressive symptoms are a major drawback of aphasia, negatively impacting on functional outcomes. In a previous study, Intensive Language-Action Therapy (ILAT) was effective in improving depression and low mood in persons with chronic non-fluent aphasia. We present a proof-of-concept case–control study that evaluates language and mood outcomes amongst persons with fluent post-stroke aphasia.

Participants: Thirteen Spanish speaking persons with fluent aphasia due to chronic stroke lesions in the left hemisphere participated in the study.

Intervention: Five participants (intervention group) received ILAT for 3 h/day during two consecutive weeks, for an overall of 30 h, and 8 participants (control group) entered a waiting-list no-treatment arm.

Results: The main finding was that participants receiving active treatment showed significant improvements on depression and aphasia severity scores, whereas no significant changes were found in the control group.

Conclusions: The implementation of ILAT was efficient in improving clinical language deficits in people with fluent aphasia and contributes to improvement in mood after therapy.

Trial registration: EUDRACT (2008-008481-12)

Acknowledgements

The authors thank all participants and carers for their cooperation during the study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The study was supported by a grant from Pfizer (Spain and USA; PI: MLB). The work has also been supported in part by the Ministerio de Economía, Industria y Competitividad, Instituto de Salud Carlos III, Madrid, Spain (PI: MLB and GD) under Grant: PI16/01514. Lisa Edelkraut has been funded by a PhD scholarship from the Spanish Ministry of Science and Innovation and Universities under the FPU program (FPU17/04136).

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