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International Journal of Environmental Health Research Volume 28, 2018 - Issue 5
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Original Articles

Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells

Asma BeltifaResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia;Faculté des Sciences Mathématiques, Physiques et Naturelles Université Tunis ElManar, Tunis, Tunisia
,
Afifa BelaidResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia
,
Vincenzo Lo TurcoDipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali of the University of Messina, Messina, ItalyORCID Iconhttp://orcid.org/0000-0001-6633-6920
ORCID Icon,
Monia MachrekiResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia
,
Hedi Ben MansourResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia
&
Giuseppa Di BellaDipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali of the University of Messina, Messina, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8103-6942
ORCID Icon
Pages 491-501 | Received 18 May 2018, Accepted 12 Jun 2018, Published online: 16 Jul 2018
 
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ABSTRACT

In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epithelial cell lines is investigated. The cytotoxic activity of cosmetic extracts is evaluated in vitro against B16 and Hep-2 human skin cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay.

This study shows that the tested cosmetic products could constitute a hazard to the consumer health and wellness and that strict safety analysis on cosmetic products needs to be carried out before they are marketed.

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