Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression

ABSTRACT

Hesperidin is a prominent flavanone found in citrus fruits that has a broad range of biological effects, including anti-inflammatory and antioxidant capabilities. The study’s objective was to evaluate the effects of hesperidin supplementation on anti-inflammatory and antioxidant parameters such as MDA, TAC, GSH, SOD, and CAT; CRP, TNF-α, IL-6, and IL-4 levels respectively, by analyzing human intervention trials. Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies. For the meta-analysis, eighteen studies were chosen. Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels. As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.

KEYWORDS:

• Citrus flavanone
• flavonoids
• inflammatory markers
• antioxidant response
• meta-regression

Acknowledgments

We sincerely thank all support from the authors.

Authors’ contributions

YB conceived the idea and conceptualized the review. YB, CDE, and FNK conducted the study selection, data extraction, and methodological quality assessment. AT, FNK drafted the initial manuscript. YB, CDE, FNK, and AT contributed to writing the manuscript. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Availability of data and materials

The tables, figures, and supplemental materials supporting the conclusions of this article are included within the article.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.