Abstract
We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26–0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57–0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62–0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56–0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56–0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73–1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin. In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.
Disclosure statement
The authors have declared no conflicts of interest.
Funding information
This work was supported by the Major Science and Technology Projects of Zhejiang province (grant number 2014C03041-1).