Fructooligosaccharide enhanced absorption and anti-dyslipidemia capacity of tea flavonoids in high sucrose-fed mice

Abstract

The ingestion of tea flavonoids (TF) and fructooligosaccharide (FOS) contributes to anti-hyperlipidaemia. In the current study, TF or FOS or TF together with FOS were orally administrated to mice fed a high sucrose (HS) diet. UPLC-MS analyses showed that FOS significantly increased the concentrations of urine catechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate and gallocatechin gallate. The mice fed with HS for continuous 8 weeks exhibited severe dyslipidemia and abnormal liver fat accumulation. However, oral administration of FOS or TF or in combination significantly decreased the effects of HS on the serum total cholesterol, total triglycerides, low-density lipoprotein and high-density lipoprotein. Co-treatment of FOS and TF more effectively regulated lipid metabolism by inhibiting lipogenesis. Intake of TF together with FOS reduced the level of dyslipidemia marker (elaidic acid) by increasing anti-oxidative activity than treatments of FOS or TP alone in HS-fed mice. Histological observations of liver confirmed these health benefits.

Keywords:

• Absorption
• dyslipidemia
• fructooligosaccharide
• sucrose
• tea flavonoids

Disclosure statement

The authors have declared no conflict of interest.

Additional information

Funding

This study was supported by Plan for supporting development of youth scientific research talent of Yangtze Normal University and the National Natural Science Foundation of China (81760083).