Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer

Abstract

Purpose: To analyse the relation between antioxidant genotypes and Dietary Antioxidant Quality score (DAQs) effect on prostate cancer (PCa) risk and aggressiveness in a Spanish population.

Methods: Men (N = 155 patients and 152 controls) with PSA values >4 ng/ml were enrolled in the project. DAQs were used considering the daily recommended intake for Spanish people (DRI). Genotyping of 5 SNPs rs662 (PON1), rs10432782 (SOD1), rs4880 (SOD2), rs17650792 (GPX1) and rs1001179 (CAT) were included for the analysis.

Results: rs17650792 was statistically significant between case and controls subjects. When comparing D´Amico risk, we found that rs662 (CC), rs10432782 (G allele) and rs17650792 (GG) confer a protection. When testing SNP-antioxidant nutrients interactions, we found an intake of vitamin A and rs100179 (T carriers) and selenium and rs17650792 (G carriers) confers a protection of being in low risk classification.

Conclusions: We reported by the first time a correlation between rs662 (PON1) and PCa aggressiveness.

Keywords:

• Dietary Antioxidant Quality Score
• oxidative stress
• prostate cancer
• SNPs

Acknowledgments

This paper will be part of MP-G’s doctorate thesis, being completed as part of the “Nutrition and Food Sciences Program” at the University of Granada, Spain. The authors would also like to thank all blood donors and staff of the Urology Service of the “Virgen de las Nieves” University Hospital, Granada, Spain, for making this study possible.

Disclosure statement

The authors declare that they have no conflict of interest.