British Journal of Biomedical Science in 2019. What have we learned?

Figures & data

Figure 1. Low levels of miR-935 are linked to a poor outcome in non-small-cell lung cancer. (from reference [38]).

Table 1. Non-coding RNAs in biomedical science.

nc-RNA species	Nature of sample	Disease	Advance	Reference
miR-935	Tissue	Non-small cell lung cancer	Low levels in malignant tissue that are linked to poor outcome	[38]
miR-25	Serum	Non-small cell lung cancer	Increased levels that are linked to stage and lymph node metastases	[39]
miR-KIF 14	Leukocytes	Breast cancer	SNP rs10800708 linked to clinical and histological grade	[40]
miR-15a	Tissue	Age-related cataract	Increased expression contributes to age-related cataracts	[42]
lncRNA GAS5	Leukocytes	Gastric cancer	SNP rs145204276 linked to presence of cancer and to stage	[43]
lncRNAs XIST	Tissue	Oesophageal carcinoma	Increased expression linked to stage, lymph node metastases and poor overall survival	[44]
miR-124	Serum	Pancreatic cancer	Decreased levels that link to lymph node metastases, stage and overall survival	[45]
miR-21	Tissue	Osteosarcoma	Increased expression linked to stage and metastases, and predicts poor prognosis	[46]
miR-146a	Tissue	Gastric cancer	SNP rs2910164 in not linked to this cancer	[47]
miR-199a-3p	Tissue	Thyroid cancer	Downregulation linked to invasion and metastases	[48]
miR-210	Serum	Rheumatoid arthritis	Low levels in rheumatoid arthritis, linked to disease activity	[49]
miR-155	Serum	Rheumatoid arthritis	High levels in rheumatoid arthritis, linked to disease activity	[49]
miR-152	Serum	Uterine sarcoma	Low levels that link to stage, lowest levels linked to poor survival	[50]
miR-24	Serum	Uterine sacroma	Low levels that link to stage, lowest levels linked to poor survival	[50]
miR-205	Serum	Uterine sarcoma	Low levels that link to stage	[50]
miR-202	Serum	Uterine sarcoma	High levels that link to stage	[50]
miR-150	Serum	Uterine sacroma	High levels that link to stage	[50]
miR-126	Leukocyte	Coronary artery disease	Low levels in diabetes, even lower in coronary artery disease, linked to hyperglycaemia	[51]
miR-210	Leukocyte	Coronary artery disease	High levels in diabetes, even higher in coronary artery disease, linked to lipids	[51]
miR34B/c	Leukocyte	Ulcerative colitis	SNP rs4938723 linked to the disease, tumour size and lymph node status	[52]
miR-27a	Leukocyte	Breast cancer	SNP rs895819 linked to the disease, tumour size and stage	[53]
miR-196a2	Leukocyte	Breast cancer	SNP rs11614913 not linked to the disease, but to tumour size, stage and lymph node status	[53]
miR-146a	Leukocyte	Breast cancer	SNP rs2910164 links to disease, tumour size, stage and lymph node status	[53]
miR-124-1	Leukocyte	Gastric cancer	SNP rs531564 links to the disease	[54]
miR-146b	Tissue	Thyroid cancer	High expression in malignant lesions compared to benign lesions	[55]

SNP: single-nucleotide polymorphism. For other examples see reference [36].

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