Association between SLCO1B1 polymorphism distribution frequency and blood lipid level in Chinese adults

Figures & data

Table 1. Demographic and laboratory characteristics of the study participants

	*1a/*1a	*1b/*1b	*1a/*1b	*1b/*15	*1a/*15 and *1b/*5	*15/*15	*1a/*5	*5/*5
Subjects (n, %)	54(8.5)	186(29.3)	134(21.1)	175(27.5)	65(10.2)	14(2.2)	5(0.8)	3(0.5)
Men (n, %)	33(61.1)	110(59.1)	74(55.2)	84(48.0)	40(61.5)	9(64.3)	2(40)	0(0)
Age (years)	48.6(12.2)	48.8(12.6)	49.4(12.7)	49.0(13.2)	50.7(13.6)	49.2(5.3)	56.0(13.8)	49.0(13.8)
Glucose (mmol/L)	5.6(2.1)	5.3(1.4)	5.7(2.0)	5.6(2.4)	5.5(1.7)	5.4(0.6)	7.0(2.7)	4.7(0.2)
Urea (mmol/L)	4.9(1.0)	5.3(2.8)	4.9(1.3)	4.9(1.7)	5.8(2.9)	5.1(1.1)	5.2(0.9)	4.1(0.3)
ALT (IU/L)	32(18.6)	27(24.3)	31(27.3)	31(45.9)	27(14.0)	51(51.5)	21(3.9)	20(4.9)
AST (IU/L)	26(10.2)	24(19.6)	25(23.6)	29(58.4)	30(46.2)	35(20.4)	19(3.1)	18(1.6)
GGT (IU/L)	50(48.0)	38(105.3)	39(38.2)	37(41.3)	46(63.2)	127(182.8)	29(8.8)	16(5.8)
Creatinine (μmol/L)	70(29.0)	67(16.7)	65(31.2)	67(32.2)	72(28.9)	64(14.9)	63(18.5)	47(3.5)
Uric Acid (μmol/L)	384(105)	356(96)	372(107)	355(110)	358(116)	368(82)	347(119)	362(12)

^aThe SNPs 521 T > C and 388A>G are within SLCO1B1. Due to methodological limitations, when the SNPs is 388AG,521 TC, it may be *1a/*15 or *1b/*5.

^bCase (%), Biochemical marker values are mean (SD).

Figure 1. Representation of possible SLCO1B1 allele/genotype combinations and their particular nucleotide composition

Table 2. Association between SLCO1B1 genotypes and serum lipids

	Cholesterol (mmol/L)	Triglycerides (mmol/L)	HDL (mmol/L)	LDL (mmol/L)
*1a/*1a	5.1(0.8)	1.3(1.0,2.2)^a	1.24(0.30)^c	3.2(0.9)
*1b/*1b	5.0(0.9)	1.1(0.8,1.6)^a,b	1.39(0.42)^c,d	3.2(1.2)
*1a/*1b	5.1(1.0)	1.3(0.9,2.1)^b	1.28(0.29)^d	3.1(0.9)
*1b/*15	5.2(1.2)	1.2(0.8,1.8)	1.34(0.36)	3.1(1.0)
P value	0.378	0.004	0.018	0.965

^ap = 0.012, ^bp = 0.041, ^cp = 0.007, ^dp = 0.015. Data mean (SD) or median (interquartile range). Overall p values by ANOVA except triglycerides – Kruskal-Wallis.

Figure 2. Association of *1a/*1a,*1b/*1b,*1a/*1b and *1b/*15 genotypes and their triglycerides levels. *, P < 0.05. ^a P = 0.012, compared *1a/*1a with *1b/*1b groups. ^b P = 0.041, compared *1b/*1b * with *1a/*1b groups. The long and short black bars, mean and SD

Figure 3. Association of *1a/*1a,*1b/*1b,*1a/*1b and *1b/*15 genotypes and their high-density lipoproteins levels. *, P < 0.05. **,P < 0.01, ^a P = 0.007, compared *1a/*1a with *1b/*1b groups.^b P = 0.015, compared *1b/*1b * with *1a/*1b groups. The long and short black bars, Mean and SD

Table

What is known about this subject? Increased serum triglycerides and reduced HDL are risk factors for cardiovascular disease Certain SLCO1B1 genotypes are linked to adverse effects of statins What this paper adds Certain SLCO1B1 genotypes are linked to increased serum triglycerides and reduced HDL Around 2.7% of this population carry SLCO1B1 genotypes that put them at risk of adverse effects of statins.