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Molecular Membrane Biology Volume 25, 2008 - Issue 2
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Original

The translocon and the non-specific transport of small molecules in the endoplasmic reticulum (Review)

Beáta Lizák Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary; the Pathobiochemistry Research Group of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
,
Miklós Csala Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary; the Pathobiochemistry Research Group of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
,
Angelo Benedetti Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
&
Gábor Bánhegyi Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary; the Pathobiochemistry Research Group of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary; Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, ItalyCorrespondence[email protected]
Pages 95-101 | Received 06 Jun 2007, Published online: 09 Jul 2009

Figures & data

Figure 1.  The three states of ribosome-translocon complex. (A) The ribosome-translocon channel is occupied by the polypeptide chain being translocated. (B) After the completion of translocation, the polypeptide leaves the channel empty. In this state, the complex allows the passage of small molecules. (C) The pore is closed again once the ribosome has been released from the translocon.

Figure 1.  The three states of ribosome-translocon complex. (A) The ribosome-translocon channel is occupied by the polypeptide chain being translocated. (B) After the completion of translocation, the polypeptide leaves the channel empty. In this state, the complex allows the passage of small molecules. (C) The pore is closed again once the ribosome has been released from the translocon.

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