Potassium channels and their role in glioma: A mini review

Figures & data

Table 1. Expression of K⁺ channels in glioma cells.

Channel	Tumor	Reference
Kv Channel	Diffuse Astrocytoma, Glioma	(Arvind et al., 2012) Kv1.5, (Preußat et al., 2003) Kv1.3 and Kv1.5, (Venturini et al., 2017) Kv1.3
KCa^2+Channel	Glioblastoma	(Catacuzzeno & Franciolini, 2018; D’Alessandro et al., 2013, 2016; Kinboshi et al., 2019; Turner et al., 2014) KCa3.1, (Debska-Vielhaber et al., 2009; Ge et al., 2014; Hoa et al., 2016; Rosa et al., 2017; Weaver et al., 2006) BK, (Huang et al., 2015; Stegen et al., 2015; Weaver et al., 2006) IK, (Weaver et al., 2006) SK
Kir Channel	Glioblastoma	(Kinboshi et al., 2019; So et al., 2014; Thuringer et al., 2017) Kir4.1, (Veeravalli et al., 2012) Kir4.2
EAG Channel	Glioblastoma	(Bai et al., 2013) EAG1
hERG Channel	Glioblastoma	(Staudacher et al., 2014)
KATP Channel	Glioma	(Huang et al., 2015; Ru et al., 2014)

Arvind S, Arivazhagan A, Santosh V, Chandramouli BA. 2012. Differential expression of a novel voltage gated potassium channel–Kv 1.5 in astrocytomas and its impact on prognosis in glioblastoma. Br J Neurosurg 26:16–20.

 PubMed Web of Science ®Google Scholar

Preußat K, Beetz C, Schrey M, Kraft R, Wölfl S, Kalff R, Patt S. 2003. Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. Neurosci Lett 346:33–36.

 PubMed Web of Science ®Google Scholar

Venturini E, Leanza L, Azzolini M, Kadow S, Mattarei A, Weller M, et al. 2017. Targeting the potassium channel Kv1.3 kills glioblastoma cells. Neurosignals 25:26–38.

 PubMedGoogle Scholar

Catacuzzeno L, Franciolini F. 2018. Role of KCa3.1 channels in modulating Ca(2+) oscillations during glioblastoma cell migration and invasion. Int J Mol Sci 19:2970.

 Web of Science ®Google Scholar

D’Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, et al. 2013. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis 4:e773.

 PubMed Web of Science ®Google Scholar

D’Alessandro G, Grimaldi A, Chece G, Porzia A, Esposito V, Santoro A, et al. 2016. KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment. Oncotarget 7:30781–30796.

 PubMedGoogle Scholar

Kinboshi M, Shimizu S, Mashimo T, Serikawa T, Ito H, Ikeda A, et al. 2019. Down-regulation of astrocytic Kir4.1 channels during the audiogenic epileptogenesis in leucine-rich glioma-inactivated 1 (Lgi1) mutant rats. Int J Mol Sci 20:E1013.

 PubMed Web of Science ®Google Scholar

Turner KL, Honasoge A, Robert SM, McFerrin MM, Sontheimer H. 2014. A proinvasive role for the Ca(2+) -activated K(+) channel KCa3.1 in malignant glioma. Glia 62:971–981.

 PubMed Web of Science ®Google Scholar

Debska-Vielhaber G, Godlewski MM, Kicinska A, Skalska J, Kulawiak B, Piwonska M, et al. 2009. Large-conductance K + channel openers induce death of human glioma cells. J Physiol Pharmacol 60:27–36.

 PubMed Web of Science ®Google Scholar

Ge L, Hoa NT, Wilson Z, Arismendi-Morillo G, Kong XT, Tajhya RB, et al. 2014. Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy. Int Immunopharmacol 22:427–443.

 PubMed Web of Science ®Google Scholar

Hoa NT, Ge L, Martini F, Chau V, Ahluwalia A, Kruse CA, Jadus MR. 2016. Temozolomide induces the expression of the glioma Big Potassium (gBK) ion channel, while inhibiting fascin-1 expression: possible targets for glioma therapy. Expert Opin Ther Targets 20:1155–1167.

 PubMed Web of Science ®Google Scholar

Rosa P, Sforna L, Carlomagno S, Mangino G, Miscusi M, Pessia M, et al. 2017. Overexpression of large-conductance calcium-activated potassium channels in human glioblastoma stem-like cells and their role in cell migration. J Cell Physiol 232:2478–2488.

 PubMed Web of Science ®Google Scholar

Weaver AK, Bomben VC, Sontheimer H. 2006. Expression and function of calcium-activated potassium channels in human glioma cells. Glia 54:223–233.

 PubMed Web of Science ®Google Scholar

Huang MH, Huang YM, Wu SN. 2015. The inhibition by oxaliplatin, a platinum-based anti-neoplastic agent, of the activity of intermediate-conductance Ca(2)(+)-activated K(+) channels in human glioma cells. Cell Physiol Biochem 37:1390–1406.

 PubMedGoogle Scholar

Stegen B, Butz L, Klumpp L, Zips D, Dittmann K, Ruth P, Huber SM. 2015. Ca2+-activated IK K + channel blockade radiosensitizes glioblastoma cells. Mol Cancer Res 13:1283–1295.

 PubMed Web of Science ®Google Scholar

So EC, Lo YC, Chen LT, Kao CA, Wu SN. 2014. High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells. Eur J Pharmacol 738:332–341.

 PubMed Web of Science ®Google Scholar

Thuringer D, Chanteloup G, Boucher J, Pernet N, Boudesco C, Jego G, et al. 2017. Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells. Oncotarget 8:37681–37693.

 PubMedGoogle Scholar

Veeravalli KK, Ponnala S, Chetty C, Tsung AJ, Gujrati M, Rao JS. 2012. Integrin alpha9beta1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway. Cell Signal 24:272–281.

 PubMed Web of Science ®Google Scholar

Bai Y, Liao H, Liu T, Zeng X, Xiao F, Luo L, et al. 2013. MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-a-go-go (EAG1). Eur J Cancer 49:710–724.

 PubMed Web of Science ®Google Scholar

Staudacher I, Jehle J, Staudacher K, Pledl HW, Lemke D, Schweizer PA, et al. 2014. HERG K + channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells. Plos One 9:e88164.

 PubMed Web of Science ®Google Scholar

Huang L, Li B, Tang S, Guo H, Li W, Huang X, et al. 2015. Mitochondrial KATP channels control glioma radioresistance by regulating ROS-induced ERK activation. Mol Neurobiol 52:626–637.

 PubMed Web of Science ®Google Scholar

Ru Q, Tian X, Wu YX, Wu RH, Pi MS, Li CY. 2014. Voltage-gated and ATP-sensitive K + channels are associated with cell proliferation and tumorigenesis of human glioma. Oncol Rep 31:842–848.

 PubMed Web of Science ®Google Scholar