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Research Article

Histological and micrometric effects of diazinon exposure on adrenal medulla and cortex in mice

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Pages 267-272 | Received 02 Nov 2011, Accepted 27 Feb 2012, Published online: 05 Apr 2012

Figures & data

Figure 1.  Mean (values shown with in the histogram bars) cortical cell size in Control and DZ treated groups.

Note:+bars = SEM; uppercase letter (A, AB and B) above the + bars indicate the statistical comparison of the means among the experimental groups [any two groups not sharing a common uppercase letter show significant difference with each other (comparison of the means based upon Duncan's Multiple Range Test: P <0.05)]. Title bar shows the F, F critical and P values of ANOVA. 9S: 9 mg/kg Single DZ exposure; 9M: 9 mg/kg Multiple DZ exposure; 18S: 18 mg/kg Single DZ exposure; and 18M: 18 mg/kg Multiple DZ exposure groups.

Figure 1.  Mean (values shown with in the histogram bars) cortical cell size in Control and DZ treated groups. Note:+bars = SEM; uppercase letter (A, AB and B) above the + bars indicate the statistical comparison of the means among the experimental groups [any two groups not sharing a common uppercase letter show significant difference with each other (comparison of the means based upon Duncan's Multiple Range Test: P <0.05)]. Title bar shows the F, F critical and P values of ANOVA. 9S: 9 mg/kg Single DZ exposure; 9M: 9 mg/kg Multiple DZ exposure; 18S: 18 mg/kg Single DZ exposure; and 18M: 18 mg/kg Multiple DZ exposure groups.

Figure 2.  Mean (values shown with in the histogram bars) medullary cell size in Control and DZ treated groups.

Note:+bars = SEM; uppercase letter (A, AB and B) above the + bars indicate the statistical comparison of the means among the experimental groups [any two groups not sharing a common uppercase letter show significant difference with each other (comparison of the means based upon Duncan's Multiple Range Test: P <0.05)]. Title Bar shows the F, F critical and P values of ANOVA. 9S: 9 mg/kg Single DZ exposure; 9M: 9 mg/kg Multiple DZ exposure; 18S: 18 mg/kg Single DZ exposure; and 18M: 18 mg/kg Multiple DZ exposure groups.

Figure 2.  Mean (values shown with in the histogram bars) medullary cell size in Control and DZ treated groups. Note:+bars = SEM; uppercase letter (A, AB and B) above the + bars indicate the statistical comparison of the means among the experimental groups [any two groups not sharing a common uppercase letter show significant difference with each other (comparison of the means based upon Duncan's Multiple Range Test: P <0.05)]. Title Bar shows the F, F critical and P values of ANOVA. 9S: 9 mg/kg Single DZ exposure; 9M: 9 mg/kg Multiple DZ exposure; 18S: 18 mg/kg Single DZ exposure; and 18M: 18 mg/kg Multiple DZ exposure groups.

Figure 3.  Control (100×) and 18M [18 mg kg−1(100×)]; C1: 9 mg kg−1 (400×) and C2: 18 mg kg−1 (400×) – adrenal Cortex in DZ multiple exposure groups; M1: 9 mg kg−1 (400×) and M2: 18 mg kg−1 (400×) – adrenal Medulla in DZ Multiple exposure groups, showing various histological abnormalities.

Note: A: Medulla; B: Zona Reticularis; C: Zona Fasciculata; D: Zona Glomerulosa; E: Central vein; F: Fat droplets in Zona Reticularis; G: Chromaffin cells apoptosis; H: Shrunken cluster of chromaffin cells due to the depletion of granules; White arrow heads: Mitotic proliferation in Zona Fasciculata.

Figure 3.  Control (100×) and 18M [18 mg kg−1(100×)]; C1: 9 mg kg−1 (400×) and C2: 18 mg kg−1 (400×) – adrenal Cortex in DZ multiple exposure groups; M1: 9 mg kg−1 (400×) and M2: 18 mg kg−1 (400×) – adrenal Medulla in DZ Multiple exposure groups, showing various histological abnormalities. Note: A: Medulla; B: Zona Reticularis; C: Zona Fasciculata; D: Zona Glomerulosa; E: Central vein; F: Fat droplets in Zona Reticularis; G: Chromaffin cells apoptosis; H: Shrunken cluster of chromaffin cells due to the depletion of granules; White arrow heads: Mitotic proliferation in Zona Fasciculata.

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