The in vitro and in vivo effects of chlorpyrifos on acetylcholinesterase activity of rainbow trout brain

Ahmet TopalDepartment of Basic Sciences, Faculty of Fisheries, Ataturk University, TR-25240Erzurum, TurkeyCorrespondence[email protected]

Melda ŞişecioğluDepartment of Molecular Biology and Genetics, Faculty of Sciences, Ataturk University, TR-25240Erzurum, Turkey

Muhammed AtamanalpDepartment of Aquaculture, Faculty of Fisheries, Ataturk University, TR-25240Erzurum, Turkey

Alparslan IşıkDepartment of Basic Sciences, Faculty of Fisheries, Ataturk University, TR-25240Erzurum, Turkey

Bahar YılmazDepartment of Molecular Biology and Genetics, Faculty of Sciences, Ataturk University, TR-25240Erzurum, Turkey

Figures & data

Figure 1. The in vivo effects of chlorpyrifos on brain AChE activity of rainbow trout. Values are expressed as mean ± S.E.M. Significant difference from control values *p < 0.05.

Table 1. IC₅₀, K_i values and inhibition types of chlorpyrifos on the enzyme activity.

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Figure 2. Determination IC⁵⁰ values of the chlorpyrifos. Acetylthiocholine iodide was used as substrate at five different concentrations. Control activity was assumed to be 100% in the absence of inhibitor.

Figure 2. Determination IC50 values of the chlorpyrifos. Acetylthiocholine iodide was used as substrate at five different concentrations. Control activity was assumed to be 100% in the absence of inhibitor.

Figure 3. Determination Ki values of the chlorpyrifos. For the determination of Ki values, three different inhibitor concentrations were tested.

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The in vitro and in vivo effects of chlorpyrifos on acetylcholinesterase activity of rainbow trout brain

Table 1. IC₅₀, K_i values and inhibition types of chlorpyrifos on the enzyme activity.

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The in vitro and in vivo effects of chlorpyrifos on acetylcholinesterase activity of rainbow trout brain

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Table 1. IC50, Ki values and inhibition types of chlorpyrifos on the enzyme activity.

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Table 1. IC₅₀, K_i values and inhibition types of chlorpyrifos on the enzyme activity.