Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs

Figures & data

Table 1. Mean, standard deviation, minimum and maximum values, and inferior (Inf) and superior (Sup) 95% confidence intervals for IGF-1 serum levels (ng/mL) in PRGF- and HPRGF-injected dogs at each study period.

	0 min	1 min	15 min	30 min	1 h	6 h	12 h	1 day	3 days
IGF-PRGF
Mean	132.70	111.54	113.21	99.14	104.91	94.11	109.81	95.60	78.31
SD	49.05	50.07	57.52	51.97	37.91	31.81	37.56	33.91	26.832
Min	83.80	44.10	56.00	43.70	58.00	54.70	42.10	50.90	55.80
Max	205.00	185.00	195.00	177.00	174.00	129.00	153.00	135.00	135.00
Inf	85.99	51.03	59.45	45.68	62.02	58.27	55.27	54.68	57.21
Sup	201.70	178.40	191.70	172.50	157.20	128.70	147.60	134.70	119.58
IGF-HPRGF
Mean	95.60	75.58	73.14	68.95	68.64	74.67	65.14	67.95	93.15
SD	31.53	30.76	27.56	26.20	23.42	26.56	19.55	20.76	25.41
Min	29.00	27.90	26.00	23.80	19.30	20.60	28.70	30.70	37.20
Max	128.00	105.00	98.40	107.00	90.70	101.00	93.10	92.60	109.00
Inf	47.87	31.26	31.55	32.41	33.31	33.62	38.12	36.67	53.40
Sup	123.20	103.35	97.11	100.46	88.39	98.63	87.31	89.12	108.70

Table 2. Mean, standard deviation, minimum and maximum values, and inferior (Inf) and superior (Sup) 95% confidence intervals for CRP serum levels (µg/mL) in PRGF- and HPRGF-injected dogs at each study period.

	0 min	1 min	15 min	30 min	1 h	6 h	12 h	1 day	3 days
CRP-PRGF
Mean	7.78	6.91	6.44	5.75	5.80	5.87	5.88	9.54	11.67
SD	5.51	4.18	4.09	4.47	4.46	3.89	4.12	5.94	4.84
Min	1.40	2.80	1.70	2.10	1.00	1.00	2.10	1.70	1.00
Max	13.800	13.10	12.70	12.70	12.30	13.10	12.80	18.30	13.20
Inf	1.61	2.92	1.94	2.10	1.54	1.66	2.22	1.82	2.54
Sup	13.77	12.65	11.83	12.37	12.09	11.33	11.90	16.62	19.25
CRP-HPRGF
Mean	16.32	14.28	14.34	13.61	14.98	17.80	16.77	15.05	7.35
SD	18.68	16.03	16.41	14.50	14.72	14.54	12.53	11.50	6.99
Min	4.00	4.00	4.00	4.00	4.00	4.00	4.00	4.00	3.00
Max	56.60	48.60	49.80	44.70	46.60	47.40	41.10	37.20	21.50
Inf	4.00	4.00	4.00	4.00	4.75	4.42	4.43	4.47	3.00
Sup	45.23	39.12	39.72	35.85	37.84	39.66	35.46	31.86	18.65

Figure 1. Evolution of IGF-1 levels in PRGF- and HPRGF-injected dogs at various time periods (logarithmic scale) up to three days post injection.

Figure 2. Evolution of CRP levels in PRGF- and HPRGF-injected dogs at various time periods (logarithmic scale) up to three days post injection.