Animal models of Shiga toxin-producing Escherichia coli infection

Figures & data

Table 1. Synopsis of Animal models, treatments, and results.

Animal type	Strain	Treatment(s)	Route of inoculation	Outcomes	Key References
Mouse	CD-1, DBA/2J	streptomycin, and most E. coli O157 strains	Administered orally	Colonization	(Myhal et al. 1982, Wadolkowski et al. 1990a)
	CD-1	streptomycin, and some Stx2 producers (such as O91:H21 strain B2F1)	Administered orally	Renal damage, death	(Melton-Celsa et al. 1996)
	ICR	streptomycin,, MMC^1), and O157:H- strain E32511/HSC	Gastric administration	Encephalopathy	(Fujii et al. 1994)
	CD-1	streptomycin, ciprofloxacin, and O157:H7 strain 1:361R	Gastric administration	Death	(Zhang et al. 2000)
	C3H/HeN	O157:H7 strain 86–24	Gastric administration	Expansion of mesangial matrix, Loose stool	(Karpman et al. 1997)
	C57BL/6	Low-protein diet, and O157:H7 strain N-9	Gastric administration	Neurologic and systemic symptoms, cerebral hemorrhages, death	(Kurioka et al. 1998)
Rabbit	NZW^2)	O157:H7 strain UC741	Gastric administration	Diarrhea, death	(Pai et al. 1986)
	NZW	O15:H- strain RDEC-H19A	Gastric administration	Diarrhea, submucosal edema and subserosal hemorrhage of the colon, as well as vascular alterations.	(Sjogren et al. 1994)
	infant NZW	most STEC strains producing Stx1	Gastric administration	Diarrhea, mucosal damage in the colon, some death	(Sherman et al. 1988)
	NZW	purified Stx1 only	Injection on ear vein	Diarrhea, Central nervous system symptoms, cecal mucosal edema and submucosal vascular alterations	(Richardson et al. 1992)
	JWR^3)	purified Stx2 only	Injection on ear vein	Hemorrhagic diarrhea, flaccid paresis, convulsions	(Fujii et al. 1996)
Chicken		O157:H7 strain ATCC 43889	Gastric administration	Colonization, attaching and effacing lesions	(Sueyoshi and Nakazawa 1994)
Dog	Greyhound	purified Stx1 or Stx2 only	Injection	Thrombocytopenia, hemorrhagic colitis, and anemia	(Proulx et al. 2001)
Pig	Gnotobiotic piglets	most STEC strains producing Stx2e	Administered orally	Diarrhea, neurological complications, death	(Gunzer et al. 2003)

¹⁾ MMC: Mitomycin C

²⁾ NZW: New Zealand White

³⁾ JWR: Japanese white rabbit

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