Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols

Figures & data

Figure 1. Benzoic 1a–e and 2a–c, phenylacetic 3a–b and cinnamic acids 4a–b used as substrates for biotransformations.

Figure 2. Bioconversions of benzoic acids 1–2 to benzyl alcohols 5–6 with Cunninghamella elegans. Conversions (%) are indicated in each case for three day incubations as averages of at least duplicate experiments.

Figure 3. Biotransformations of aromatic carboxylic acids 1a–e, 2a–c, 3a–b, 4a–b to amides 7a–e, 8a–c, 9a–b, 10a–b with Streptomyces sp. JCM9888. Conversions are indicated in each case for six day incubations of the various substrates.