Prevalence and cumulative 5-year incidence of chronic lymphocytic leukemia in the adult population in the Russian Federation and Ukraine: Data from the LEUKOSPECT study

Figures & data

Table 1 Summary of the total adult population characteristics

	Yekaterinburg, Russia			Khabarovsk, Russia			Luhansk, Ukraine
Study year	All	Male	Female	All	Male	Female	All	Male	Female
Year 2009 (01 January 2010)	1 124 480	488 820	635 660	477 306	223 581	253 725	374 089	161 652	212 437
Year 2010 (01 January 2011)	1 131 973	492 077	639 896	474 912	222 460	252 452	370 855	160 254	210 601
Year 2011 (01 January 2012)	1 152 271	501 825	650 446	480 262	224 831	255 431	367 649	158 879	208 770
Year 2012 (01 January 2013)	1 167 118	512 365	654 753	485 272	227 602	257 670	366 496	158 381	208 115
Year 2013 (01 January 2014)	1 180 721	518 337	662 384	489 077	229 085	259 992	365 003	157 736	207 267

Figure 1 Age intervals and population proportions of incidence cases at the end of data collection.

Figure 2 Age intervals and population proportions of prevalence cases at the end of data collection.

Table 2 Baseline characteristics of CLL incidence cases in the adult population (cumulative 5-year incidence)

		Yekaterinburg, Russia			Khabarovsk, Russia			Luhansk, Ukraine
		Sex			Sex			Sex
		Female (N = 39)	Male (N = 45)	All (N = 84)	Female (N = 47)	Male (N = 57)	All (N = 104)	Female (N = 42)	Male (N = 38)	All (N = 80)
Age at the end of data collection (31 December 2013), years	Mean	68	67	68	70	69	69	70	65	68
	SD	9	9	9	11	12	11	9	10	10
	Min	46	47	46	38	35	35	50	46	46
	Max	85	84	85	89	94	94	91	89	91
Age at CLL diagnosis, years	Mean	66	65	65	68	67	67	67	63	65
	SD	9	10	9	10	11	11	9	10	10
	Min	44	45	44	37	31	31	50	46	46
	Max	82	83	83	87	89	89	89	89	89
Race	Caucasian	100% (39)	100% (45)	100% (84)	100% (47)	100% (58)	100% (105)	100% (42)	100% (38)	100% (80)

CLL, chronic lymphoid leukemia; SD, standard deviation. Data cutoff: 31 December 2013.

Table 3 Baseline characteristics of CLL prevalence cases in the adult population

		Yekaterinburg, Russia			Khabarovsk, Russia			Luhansk, Ukraine
		Sex			Sex			Sex
		Female (N = 39)	Male (N = 45)	All (N = 84)	Female (N = 48)	Male (N = 59)	All (N = 107)	Female (N = 42)	Male (N = 38)	All (N = 80)
Age at the end of data collection (31 December 2013), years	Mean	68	67	68	70	69	69	70	65	68
	SD	9	9	9	11	11	11	9	10	10
	Min	46	47	46	38	35	35	50	46	46
	Max	85	84	85	89	94	94	91	89	91
Age at CLL diagnosis, years	Mean	66	65	65	67	66	67	67	63	65
	SD	9	10	9	10	11	11	9	10	10
	Min	44	45	44	37	31	31	50	46	46
	Max	82	83	83	87	89	89	89	89	89
Race	Caucasian	100% (39)	100% (45)	100% (84)	100% (48)	100% (59)	100% (107)	100% (42)	100% (38)	100% (80)

CLL, chronic lymphoid leukemia; SD, standard deviation. Data cutoff: 31 December 2013.

Table 4 Cumulative 5-year (2009–2013) incidence of CLL among adult populations

City	Incidence, year	Cases	Population	Incidence	95% CI, range
Yekaterinburg, Russia	2009	11	1 124 480	0.98	0.49–1.75
	2010	19	1 131 973	1.68	1.01–2.62
	2011	12	1 152 271	1.04	0.54–1.82
	2012	20	1 167 118	1.71	1.05–2.65
	2013	22	1 180 721	1.86	1.17–2.82
	Mean	16.80	1 151 312.60	1.46	0.85–2.34
Khabarovsk, Russia	2009	25	477 306	5.24	3.39–7.73
	2010	18	474 912	3.79	2.25–5.99
	2011	14	480 262	2.92	1.59–4.89
	2012	23	485 272	4.74	3.00–7.11
	2013	24	489 077	4.91	3.14–7.30
	Mean	20.80	481 365.80	4.32	2.67–6.62
Luhansk, Ukraine	2009	13	374 089	3.48	1.85–5.94
	2010	15	370 855	4.04	2.26–6.67
	2011	12	367 649	3.26	1.69–5.70
	2012	18	366 496	4.91	2.91–7.76
	2013	22	365 003	6.03	3.78–9.13
	Mean	16.00	368 818.40	4.34	2.48–7.04

CI, confidence interval.

Table 5 Cumulative 5-year (2009–2013) sex-adjusted incidence of CLL in adult populations

City	Incidence, year	Sex	Cases	Population	Incidence	95% CI, range	Male-to-female ratio
Yekaterinburg, Russia	2009	Male	3	488 820	0.61	0.13–1.79	1.49
	2010	Male	12	492 077	2.44	1.26–4.26
	2011	Male	6	501 825	1.20	0.44–2.60
	2012	Male	11	512 365	2.15	1.07–3.84
	2013	Male	13	518 337	2.51	1.34–4.29
	Mean	Male	9.00	502 684.80	1.79	0.82–3.40
	2009	Female	8	635 660	1.26	0.54–2.48
	2010	Female	7	639 896	1.09	0.44–2.25
	2011	Female	6	650 446	0.92	0.34–2.01
	2012	Female	9	654 753	1.37	0.63–2.61
	2013	Female	9	662 384	1.36	0.62–2.58
	Mean	Female	7.80	648 627.80	1.20	0.51–2.39
Khabarovsk, Russia	2009	Male	15	223 581	6.71	3.76–11.06	1.38
	2010	Male	9	222 460	4.05	1.85–7.68
	2011	Male	5	224 831	2.22	0.72–5.19
	2012	Male	13	227 602	5.71	3.04–9.77
	2013	Male	15	229 085	6.55	3.66–10.80
	Mean	Male	11.40	225 511.80	5.06	2.56–8.95
	2009	Female	10	253 725	3.94	1.89–7.25
	2010	Female	9	252 452	3.57	1.63–6.77
	2011	Female	9	255 431	3.52	1.61–6.69
	2012	Female	10	257 670	3.88	1.86–7.14
	2013	Female	9	259 992	3.46	1.58–6.57
	Mean	Female	9.40	255 854.00	3.67	1.71–6.88
Luhansk, Ukraine	2009	Male	6	161 652	3.71	1.36–8.08	1.19
	2010	Male	5	160 254	3.12	1.01–7.28
	2011	Male	6	158 879	3.78	1.39–8.22
	2012	Male	9	158 381	5.68	2.60–10.79
	2013	Male	12	157 736	7.61	3.93–13.29
	Mean	Male	7.60	159 380.40	4.77	2.00–9.56
	2009	Female	7	212 437	3.30	1.32–6.79
	2010	Female	10	210 601	4.75	2.28–8.73
	2011	Female	6	208 770	2.87	1.05–6.26
	2012	Female	9	208 115	4.32	1.98–8.21
	2013	Female	10	207 267	4.82	2.31–8.87
	Mean	Female	8.40	209 438.00	4.01	1.77–7.78

CI, confidence interval.

Figure 3 Cumulative 5-year (2009–2013) age-adjusted incidence of CLL among adult populations.

Table 6 Cumulative 5-year (2009–2013) prevalence of CLL among adult populations

City	Prevalence, year	Cases	Population	Prevalence	95% CI, range
Yekaterinburg, Russia	2009	11	1 124 480	0.98	0.49–1.75
	2010	30	1 131 973	2.65	1.79–3.78
	2011	42	1 152 271	3.64	2.63–4.93
	2012	62	1 167 118	5.31	4.07–6.81
	2013	84	1 180 721	7.11	5.67–8.81
	Mean	45.80	1 151 312.60	3.98	2.91–5.31
Khabarovsk, Russia	2009	28	477 306	5.87	3.90–8.48
	2010	46	474 912	9.69	7.09–12.92
	2011	60	480 262	12.49	9.53–16.08
	2012	83	485 272	17.10	13.62–21.20
	2013	107	489 077	21.88	17.93–26.44
	Mean	64.80	481 365.80	13.46	10.39–17.16
Luhansk, Ukraine	2009	13	374 089	3.48	1.85–5.94
	2010	28	370 855	7.55	5.02–10.91
	2011	40	367 649	10.88	7.77–14.81
	2012	58	366 496	15.83	12.02–20.46
	2013	80	365 003	21.92	17.38–27.28
	Mean	43.80	368 818.40	11.88	8.62–15.95

CI, confidence interval.

Table 7 Sex-adjusted 5-year (2009–2013) prevalence of CLL in adult populations

	Prevalence, year	Sex	Cases	Population	Prevalence	95% CI, range
Yekaterinburg, Russia	2009	Male	3	488 820	0.61	0.13–1.79
	2010	Male	15	492 077	3.05	1.71–5.03
	2011	Male	21	501 825	4.18	2.59–6.40
	2012	Male	32	512 365	6.25	4.27–8.82
	2013	Male	45	518 337	8.68	6.33–11.62
	Mean	Male	23.20	502 684.80	4.62	2.93–6.91
	2009	Female	8	635 660	1.26	0.54–2.48
	2010	Female	15	639 896	2.34	1.31–3.87
	2011	Female	21	650 446	3.23	2.00–4.94
	2012	Female	30	654 753	4.58	3.09–6.54
	2013	Female	39	662 384	5.89	4.19–8.05
	Mean	Female	22.60	648 627.80	3.48	2.20–5.25
Khabarovsk, Russia	2009	Male	17	223 581	7.60	4.43–12.17
	2010	Male	26	222 460	11.69	7.63–17.12
	2011	Male	31	224 831	13.79	9.37–19.57
	2012	Male	44	227 602	19.33	14.05–25.95
	2013	Male	59	229 085	25.75	19.61–33.22
	Mean	Male	35.40	225 511.80	15.70	10.96–21.79
	2009	Female	11	253 725	4.34	2.16–7.76
	2010	Female	20	252 452	7.92	4.84–12.23
	2011	Female	29	255 431	11.35	7.60–16.30
	2012	Female	39	257 670	15.14	10.76–20.69
	2013	Female	48	259 992	18.46	13.61–24.48
	Mean	Female	29.40	255 854.00	11.49	7.72–16.46
Luhansk, Ukraine	2009	Male	6	161 652	3.71	1.36–8.08
	2010	Male	11	160 254	6.86	3.43–12.28
	2011	Male	17	158 879	10.70	6.23–17.13
	2012	Male	26	158 381	16.42	10.72–24.05
	2013	Male	38	157 736	24.09	17.05–33.07
	Mean	Male	19.60	159 380.40	12.30	7.47–19.07
	2009	Female	7	212 437	3.30	1.32–6.79
	2010	Female	17	210 601	8.07	4.70–12.92
	2011	Female	23	208 770	11.02	6.98–16.53
	2012	Female	32	208 115	15.38	10.52–21.71
	2013	Female	42	207 267	20.26	14.61–27.39
	Mean	Female	24.20	209 438.00	11.55	7.42–17.16

CI, confidence interval.

Figure 4 Age-adjusted CLL prevalence for the 5-year period (2009–2013).