Peripheral and bone marrow CD34⁺ cell levels on chronic myeloproliferative disease

Figures & data

Table 1 Patients general characteristics.

	PV		ET		PMF
Variables	n	%	n	%	n	%
Sex
Female (n:58)	27	46.6	22	37.9	9	15.5
Male (n:45)	29	64.4	10	22.2	6	13.3
Constitutional symptoms
Negative (n:72)	36	64.3	24	75	12	80
Positive (n:31)	20	35.7	8	25	3	20
Smoking
None (n:88)	45	51.1	29	33	14	15.9
Smoker (n:5)	4	80			1	20
Exsmoker (n:10)	7	70	3	30
Hypertension
Negative (n:64)	32	50.0	21	32.8	11	17.2
Positive (n:39)	24	61.5	11	28.2	4	10.3
Type 2 DM
Negative (n:95)	51	53.7	30	31.6	14	14.7
Positive (n:8)	5	62.5	2	25.0	1	12.5
AHD
Negative (n:96)	52	54.2	31	32.3	13	13.5
Positive (n:7)	4	57.1	1	14.3	2	28.6
Hyperlipidemia
Negative (n:94)	51	54.3	29	30.9	14	14.9
Positive (n:9)	5	55.6	3	33.3	1	11.1
CVE
Negative (n:99)	53	53.5	31	31.3	15	15.2
Positive (n:4)	3	75.0	1	25.0
Fibrosis
Grade 0	16	28.6	20	62.5
Grade 1	22	39.3	12	37.5
Grade 2	14	25			3	20
Grade 3	4	7.1			12	80

n: number; %: percentage; DM: diabetes mellitus; AHD: atherosclerotic heart disease; CVE: cerebrovascular events; PV: polistemia vera; ET: essential thrombocytosis; PMF: primary myelofibrosis.

Table 2 Median value of laboratory parameters.

	Subgroups
	PV	ET	PMF
Hemoglobin (g/dl)	17.03	13.60	10.66
Hematocrit (%)	52.46	40.10	31.70
Leukocyte (per u)	13 293	9739	8846
Platelets (per ul)	611 937	841 987	338 820
TS (%)	14.89	18.40	17.97
Ferritin (ng/ml)	24	53	100
LDH (U/l)	324	281	621

TS: transferrin saturation; LDH: lactate dehydrogenase; PV: polistemia vera; ET: essential thrombocytosis; PMF: primary myelofibrosis.

Table 3 Peripheral and bone marrow CD34⁺ group and median value.

	PV	ET	PMF
Peripheral CD34^+ group
<15 × 10^6	15	13	3
≥15 × 10^6	1	3	9
Median value	2.3 ± 4.3 × 10^6/l	3.8 ± 60.3 × 10^6/l	30.8 ± 122.2 × 10^6/l
Bone marrow CD34^+ group
<1%	23	10	6
≥1%	33	22	9
Median value	1 ± 0.9%	1 ± 0.9%	1 ± 1.1%

PV: polistemia vera; ET: essential thrombocytosis; PMF: primary myelofibrosis.

Table 4 Relationship between peripheral CD34⁺ level and bone marrow fibrosis stage.

	Fibrosis grade							P
Peripheral CD34	Grade 0	Grade 1	Grade 2	Grade 3	Grade 4	Pre-fibrosis	Fibrosis
<15 × 10^6	6	13	15	2	0	19	17	0.024
≥15 × 10^6	0	2	2	10	0	2	12
Total	6	15	17	12	0	21	29