JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia

Figures & data

Figure 1. The two types of CALR mutations identified in this study. L367fs*46 (52 nucleotide deletion) and K385fs*47 (TTGTC insertion).

Table 1. Clinical and hematologic characteristics according to gene mutation status.

Feature	CALR + (n = 19)	JAK2 + (n = 60)	Triple − (n = 33)
Age (years); mean	53.5	61.7	40.4
Male sex; n	9	25	15
Hemoglobin (g/l); median	126	138	127
Hct (%)	39.6	42.1	39.7
WBC count (× 10^9/l); median	10.6	12.1	8.9
Platelet count (× 10^9/l); median	1006	771	641
LDH (U/l)	396	410	378
Thrombotic event	1	9	2
Splenomegaly	0	8	2

Table 2. Characteristics of two patients with both CALR and JAK2 V617F mutations.

Feature	Patient 1#	Patient 2#
Age (years)	79	64
Sex	Male	Female
Hemoglobin (g/l)	151	136
WBC count (× 10^9/l)	15.3	12.8
Platelet count (× 10^9/l)	486	858
LDH (U/l)	296	354
Therapy	Hydroxyurea	Hydroxyurea