CD25 as an adverse prognostic factor in elderly patients with acute myeloid leukemia

Figures & data

Figure 1. CD25 expression in healthy volunteers and patients with AML (A), in a patient with CD25-positive AML (B), in patients with AML at diagnosis and relapse (C), and in patients with secondary AML and myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) (D). Leukemic cells from an AML patient, which were identified by forward and side scatter properties, expressing CD25 and coexpressing CD34 and CD7 at significant levels (B).

Table 1. Patient characteristics.

	CD25+ AML (n = 21)		CD25− AML (n = 133)		p
	n	%	n	%
Sex, male	11	52	74	56	0.78
Age, years (median, range)	68 (61–85)		69 (60–83)		0.78
≧75 years	7	33	33	25	0.4
PS ≧ 2	10	48	25	19	0.003
WBC, ×1000/μl (median, range)	9.3 (0.8–30.2)		5.3 (0.1–271.2)		0.078
Bone marrow blasts, % (median, range)	43 (19–94.6)		53 (11.5–97)		0.63
De novo AML
M0	4	19	9	7	0.14
M1	2	10	15	11	0.89
M2	2	10	43	32	0.06
M3	0	0	13	10	0.28
M4	4	19	19	14	0.81
M5	1	5	3	2	0.95
M6	1	5	5	4	0.7
M7	0	0	0	0	–
Secondary AML	7	33	23	17	0.085
Therapy-related AML	0	0	3	2	0.88
Cytogenetic
Favorable	0	0	22/128	17	0.084
Intermediate	14	67	75/128	59	0.48
Poor	7	33	31/128	24	0.37

AML: acute myeloid leukemia; n: number; PS: performance status; WBC: white blood cells.

Figure 2. Positivity of surface antigen expression in CD25-positive (CD25+) and CD25-negative (CD25−) AML.

Figure 3. Kaplan–Meier estimates of event-free (A) and overall (B) survival in patients with CD25-positive (CD25+) and CD25-negative (CD25−) non-APL AML. APL: acute promyelocytic leukemia; n: number.

Table 2. Univariate and multivariate analysis for event free survival.

Variables	Univariate (log rank)		Multivariate
	Factor	p	HR (95% CI)	p
CD25	≧10%	<.0001	2.1 (1.03–4.1)	0.040
Cytogenetic	Unfavorable	0.0048	1.8 (1.04–3.2)	0.036
Age	≧75 years	0.0021	2.8 (1.6–5.0)	0.001
Disease status	Secondary	0.0001	2.4 (1.3–4.2)	0.004
PS	≧2	0.0021	2.2 (1.3–4.0)	0.005
WBC	≧20 000/μl	0.895

HR: hazard risk; CI: confidential interval; PS: performance status; WBC: white blood cells.