Haemoglobin F, A2, and S levels in subjects with or without sickle cell trait in south-eastern Gabon

Figures & data

Table 1. Comparison of mean levels of HbF and HbA2 in different groups of Gabonese subjects living in a semi-rural area (Franceville)

Subjects		HbF levels	p-value	HbA2 levels	p-value
Sex	Women (n = 547)	0.71 ± 2.620	0.143	3.02 ± 0.582	0.032
	Men (n = 240)	0.44 ± 1.710		3.11 ± 0.526
	Total (n = 787)	0.63 ± 2.382		3.04 ± 0.567
Age	<15 years (n = 161)	0.12 ± 0.403	0.002	3.02 ± 0.458	0.565
	≥15 years (n = 626)	0.76 ± 2.647		3.05 ± 0.591
	Total (n = 787)	0.63 ± 2.382		3.04 ± 0.567
Pregnant	No (n = 511)	0.72 ± 2.690	0.631	3.03 ± 0.566	0.022
	Yes (n = 34)	0.50 ± 1.308		2.79 ± 0.770
	Total (n = 545)	0.71 ± 2.626		3.02 ± 0.583
Haemoglobin status	AA (n = 581)	0.59 ± 2.566	0.497	2.92 ± 0.512	<0.001
	AS (n = 206)	0.72 ± 1.762		3.40 ± 0.566
	Total (n = 787)	0.63 ± 2.382		3.04 ± 0.567

Note: Bold values are statistically significant with p-value < 0.05.

Table 2. Distribution of HPHF forms and HbA2 ranges in different groups of Gabonese subjects living in a semi-rural area (Franceville)

Subjects		HbA2 ranges				HPFH forms
		≤2.5%	2.6–3.5%	>3.5%	P-value	Non	Hetero	Pan	P-value
Sex	Women	79	408	60	<0 . 001	466	67	14	0.047
	Men	22	172	46		217	19	4
Age (years)	<15	14	127	20	0 . 006	155	6	0	< 0 . 001
	≥15	83	505	38		528	80	18
Pregnant	No	68	384	59	0 . 002	436	62	13	0.640
	Yes	11	22	1		28	5	1
Haemoglobin status	AA	97	441	43	<0 . 001	514	55	12	0.020
	AS	4	139	63		169	31	6

Note: Bold values are statistically significant with p-value < 0.05.

Figure 1. Bimodal distribution of HbA2 levels in subjects without sickle cell trait.

Figure 2. Trimodal distribution of HbS levels in subjects with sickle cell trait.