Microsatellite Instability and Promoter Hypermethylation of DNA repair genes in Hematologic Malignancies: a forthcoming direction toward diagnostics

Figures & data

Figure 1. Mechanism of DNA Mismatch Repair system.

Figure 2. Role of MGMT in Direct Reversal of DNA Damage system.

Table 1. List of cytogenetics markers in lymphoid and myeloid malignancies.

Cancer types	Cytogenetic biomarkers
AML	t(8;22)(q22;q22), inv(16), t(15;17)(q22;q12), t(9;11)(p22;q23), t(6;9)(p23;q34), inv(3), t(1;22)(p13;q13)
B-ALL	t(12;21)(p12;q22), t(1;19)(q23;p13), t(9;22)(q34;q11) ABL/BCR
MDS	del(5q), del(7q), +8, −Y, del(20q), (i)(17q), del(13q), del(11q), del(12p), del(9q), (idic)(Xq13)
CML	t(9;22)(q34;q11), t(11;22)
ALL	t(9;22), t(12;21), t(8;14), t(2;8), t(8;22), t(11q)
Acute T-CLL	t(11;14)
Non-Hodgkin lymphoma	t(10;14)(q24;q32), del(11q), del(13q), del(17p), t(1;1)(p36;q21), t(3;Var)(q27;Var), +3, t(9;17)(q34;q23), t(3;12)(q27;q23)

Figure 3. Test criteria for haematologic malignancies.