Predicting anxiety responses to halogenated glucocorticoid drugs using the hexobarbital sleep time test

Figures & data

Figure 1. A frequency histogram showing distributions of the number of fast and slow metabolizing rats as a function of hexobarbital sleep duration. FM, fast metabolizers of triamcinolone acetonide; SM, slow metabolizers of triamcinolone acetonide. Abscissa, sleep duration, min; ordinate, number of rats.

Table 1. Effect of triamcinolone acetonide (TA) on serotonin concentration and MAO-A activity in brain structures of fast and slow metabolizers of TA.

Groups	FM, control	FM, TA treatment	SM, control	SM, TA treatment
N	13	13	7	254 ± 24*
MO serotonin (pg/mg tissue)	540 ± 69	489 ± 85	578 ± 43	260 ± 34*
MB serotonin (pg/mg tissue)	384 ± 49	352 ± 52	412 ± 27	214 ± 13*
COR serotonin (pg/mg tissue)	265 ± 69	254 ± 40	305 ± 23	1.89 ± 0.18**
MO MAO-A (nmol/g protein/min)	1.15 ± 0.27	1.45 ± 0.23	0.93 ± 0.078	1.245 ± 0.068**
MB MAO-A (nmol/g protein/min)	0.91 ± 0.12	0.98 ± 0.073	0.83 ± 0.027	3.00 ± 0.19*
COR MAO-A, (nmol/gr protein/min)	2.31 ± 0.46	2.41 ± 0.12	2.19 ± 0.31	3.00 ± 0.19*

Values are means ± SD. FM: fast metabolizers of triamcinolone acetonide; SM: slow metabolizers of triamcinolone acetonide; MO: medulla oblongata; MB: midbrain; COR: cortex.

* Significantly different from respective, untreated control, p < 0.05.

** Significantly different from respective, untreated control, p < 0.01.

Figure 2. Regulation of MAO-dependent responses to glucocorticoids by intensity of hepatic microsomal oxidation in fast and slow metabolizers of triamcinolone acetonide. GC: glucocorticoid; MAO: monoamine oxidase; PTSD: posttraumatic stress disorder.