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Stress
The International Journal on the Biology of Stress
Volume 21, 2018 - Issue 4
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Short Communication

Pasireotide treatment does not modify hyperglycemic and corticosterone acute restraint stress responses in rats

Antônio Ribeiro-Oliveira JrDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Correspondence[email protected]
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,
Junia R. O. L SchweizerDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Pedro H. S. AmaralDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Mariana F. BizziDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Warley Cezar da SilveiraDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Daniel T. A. Espirito-SantoDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Giancarlo ZilleDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Beatriz S. SoaresDepartment of Internal Medicine, Laboratory of Endocrinology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; View further author information
,
Herbert A. SchmidDepartment of Oncology Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland; View further author information
&
Kevin C. J. YuenDepartment of Neuroendocrinology, Barrow Pituitary Center, Barrow Neurological Institute, Phoenix, AZ, USAView further author information
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Pages 370-375 | Received 14 Feb 2018, Accepted 03 Mar 2018, Published online: 17 Apr 2018

Figures & data

Figure 1. Effects of restraint stress upon plasma glucose levels in rats treated with pasireotide. VEH (N = 9): control rats submitted to restraint stress; PASR (N = 8): pasireotide-treated rats submitted to restraint stress. PASRN: pasireotide-treated rats receiving a 0.9% saline infusion and not submitted to restraint stress #p < .05 for comparisons with baseline; ##p < .001 for comparisons with baseline; **p < .01 for comparisons with baseline; Δp < .05 for comparisons with PASNR.

Figure 1. Effects of restraint stress upon plasma glucose levels in rats treated with pasireotide. VEH (N = 9): control rats submitted to restraint stress; PASR (N = 8): pasireotide-treated rats submitted to restraint stress. PASRN: pasireotide-treated rats receiving a 0.9% saline infusion and not submitted to restraint stress #p < .05 for comparisons with baseline; ##p < .001 for comparisons with baseline; **p < .01 for comparisons with baseline; Δp < .05 for comparisons with PASNR.

Figure 2. Effects of restraint stress upon plasma corticosterone levels in rats treated with pasireotide. VEH (N = 9): control rats submitted to restraint stress; PASR (N = 8): pasireotide-treated rats submitted to restraint stress. PASRN: pasireotide-treated rats receiving a 0.9% saline infusion and not submitted to restraint stress. **p < .01 for comparisons with baseline; ##p < .01 for comparisons with baseline; +p < .05 for comparisons with baseline; ++p < .01 for comparisons with baseline; ♦♦p < .01 for comparisons with PASNR.

Figure 2. Effects of restraint stress upon plasma corticosterone levels in rats treated with pasireotide. VEH (N = 9): control rats submitted to restraint stress; PASR (N = 8): pasireotide-treated rats submitted to restraint stress. PASRN: pasireotide-treated rats receiving a 0.9% saline infusion and not submitted to restraint stress. **p < .01 for comparisons with baseline; ##p < .01 for comparisons with baseline; +p < .05 for comparisons with baseline; ++p < .01 for comparisons with baseline; ♦♦p < .01 for comparisons with PASNR.

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