Figures & data
Figure 1. Total body weight (g). CORT treatment inhibited weight gain in male and female rats after a week of treatment (Treatment * Sex Interaction: *=0.026) and continued through experiment end (Treatment * Sex Interaction: *=0.018). #=0.0001, males weighed more than females.
Figure 2. Glucocorticoid Receptor. CRTL males had significantly greater GR in gonadal (p = .032), inguinal (p = .003) and visceral (p = .008) adipose depots compared with CRTL females. GR concentration was significantly higher in the visceral depot (p = .021) of CORT treated males compared with CORT treated females.
Figure 3. 11 beta-hydroxysteroid dehydrogenase 1. 11β-HSD1 was significantly higher (p = .028), in the gonadal depot of CORT female rats compared with CORT males. CORT treatment decreased 11β-HSD1 In the inguinal depot of females only (p = .042).
Figure 4. Interlukin-1 beta. Compared with male rats, IL-1β was significantly higher in the gonadal depot of females ((CTRL females vs. CTRL males; p = .05) (CORT females vs. CORT males; p = .004)). IL-1β was also significantly higher in the visceral depot of female rats compared with males ((CTRL females vs. CTRL males; p = .004) (CORT females vs. CORT males; p = .01)). CTRL female rats had significantly higher IL-1β, ∼2X, in the inguinal depot compared with males (p = .05). CORT treatment significantly increased IL-1β concentration in the gonadal depot of female (p = .003) and male (p = .008) rats, but CORT reduced IL-1β in the inguinal depot of female rats only (CORT vs. CTRL: p = .005).
Figure 5. Representative western blots images for . Gonadal (Go), Inguinal (Ing), and Mesenteric (Mes) and adipose tissue. The 3 left bands of the blot are CORT treated rats and 3 right ones are CTRL. Two representative blots are present for each antibody quantified.
