Stress

The International Journal on the Biology of Stress

Volume 25, 2022 - Issue 1

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Research Articles

Immune cell dynamics in response to an acute laboratory stressor: a within-person between-group analysis of the biological impact of early life adversity

Laura Etzela Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USAView further author information

Abner T. Apsleya Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USAView further author information

Brooke C. Matterna Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USAView further author information

Waylon J. Hastingsa Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USAView further author information

Thomas Hellera Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USAView further author information

Nilam Ramb Department of Psychology and Department of Communication, Stanford University, Stanford, CA, USAView further author information

Sue Rutherford Siegela Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USAView further author information

Idan Shaleva Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USACorrespondence[email protected]
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Figures & data

Table 1. Summary statistics for the sample. Immune cell counts are averaged across all 8 time-points in both sessions.

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Figure 1. Study design for both sessions (TSST and no-stress condition). Sessions were separated by one week. Time is denoted as minutes measured from the 15-minute long TSST or resting condition (0 = midway point in session).

Graph [77 words]: line graph of change in total white blood cell counts in 1,000 cells per microliter of blood across time for four groups: control exposed to TSST, control exposed to no stress, ELA exposed to TSST, ELA exposed to no stress. From -30 to 90 minutes all four groups experience increased white blood cell counts with the ELA exposed to TSST experiencing a larger increase than the other groups. This increase levels off from 90 to 240 minutes.

Table 2. Final best fit models for each cell type.

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Figure 2. Total white blood cell counts (Est ± SE) across time within the ELA group vs. control group in the TSST and no-stress sessions. Time is denoted as minutes measured from the 15-minute long TSST or resting condition (0 = midway point of session).

(a). Graph [65 words]: line graph of change in raw lymphocyte per microliter of blood across time for four groups: control exposed to TSST, control exposed to no stress, ELA exposed to TSST, ELA exposed to no stress. From -30 to 30 minutes all four groups experience a slight decrease in lymphocytes. From 30 to 240 minutes all four groups experience an increase in lymphocytes above baseline. (b). Graph [50 words]: Line graph of change in raw monocytes per microliter of blood across time for four groups: control exposed to TSST, control exposed to no stress, ELA exposed to TSST, ELA exposed to no stress. There is no trend of change across the four groups from -30 to 240 minutes. (c). Graph [70 words]: line graph of change in neutrophils per microliter of blood across time for four groups: control exposed to TSST, control exposed to no stress, ELA exposed to TSST, ELA exposed to no stress. From -30 to 90 minutes all four groups experience increased neutrophil counts with the ELA exposed to TSST experiencing a larger increase than the other groups. This increase levels off from 90 to 240 minutes. (d). Graph [49 words]: line graph of change in log-eosinophils per microliter of blood across time for four groups: control exposed to TSST, control exposed to no stress, ELA exposed to TSST, ELA exposed to no stress. There is no trend of change across the four groups from -30 to 240 minutes. (e). Graph [101 words]: line graph of change in raw basophils per microliter of blood across time for four groups: control exposed to TSST, control exposed to no stress, ELA exposed to TSST, ELA exposed to no stress. From -30 to 90 minutes all four groups experience increased basophil counts with the ELA exposed to TSST experiencing a larger increase than the other groups. From 90 to 240 minutes the ELA groups in both the TSST and no stress and the control exposed to no stress experience a slight drop in basophil counts, while the control exposed to the TSST continues to increase.

Figure 3. Immune cell counts (Est ± SE) across time for ELA-group vs. control-group within the TSST and no-stress conditions. Time is denoted as minutes measured from the 15-minute long TSST or resting condition (0 = midway point of session).

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Immune cell dynamics in response to an acute laboratory stressor: a within-person between-group analysis of the biological impact of early life adversity

Table 1. Summary statistics for the sample. Immune cell counts are averaged across all 8 time-points in both sessions.

Table 2. Final best fit models for each cell type.

Supplemental Material

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Immune cell dynamics in response to an acute laboratory stressor: a within-person between-group analysis of the biological impact of early life adversity

Figures & data

Table 1. Summary statistics for the sample. Immune cell counts are averaged across all 8 time-points in both sessions.

Table 2. Final best fit models for each cell type.

Supplemental Material

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