Figures & data
Figure 1. The B-flat model. Compared to the physiological situation, there are two distinct ways to achieve a disturbed B-level via subcutaneous implantation of pellets. In a classic overexposure model, hormone levels are high and mimic Cushing’s disease, chronic treatment with synthetic steroids, and perhaps chronic severe stress. The consequences of such a regimen may be due to either overall GC over-exposure or to a lack of circadian rhythmicity. In the B-Flat model, the implanted pellet leads to increased trough levels that suffice to activate negative feedback, likely involving the MR. This leads to reduced adrenocortical output and a flattened rhythm in the absence of overall 24 hour higher exposure to hormones. Created with Biorender.com.
