How an appreciation of dynamics has altered our understanding of the HPA axis

Figures & data

Figure 1. The U-RHYTHM microdialysis system and example data. Top left: Samples are collected using a linear microdialysis catheter placed superficially in abdominal subcutaneous tissue. The samples are fractionated and stored in the sample collector. Top right: the system is body worn and allows most normal activities to continue during the sampling period. Bottom: Data from a single volunteer (red line) and their sleep period (grey shaded area) are shown against the background variation of 214 healthy controls (blue lines) with interquartile range (bold is 50^th centile, dashed lines 5^th to 95^th).