Publication Cover
Stress
The International Journal on the Biology of Stress
Volume 27, 2024 - Issue 1
294
Views
0
CrossRef citations to date
0
Altmetric
Research Article

HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment

, , , , , , , , , , , , & show all
Article: 2303634 | Received 16 Aug 2023, Accepted 02 Jan 2024, Published online: 18 Jan 2024

Figures & data

Figure 1. Consort diagram of our cross-sectional study. N = 172 participants were screened for eligibility in the study, with 172 meeting initial inclusion/exclusion criteria and approached for consent. N = 141 participants consented to participation (81.9%) with 99 returning for the in-person clinical interview (69.5%). N = 88 (89.8%) participants with usable data necessary for PTSD symptom severity analysis, N = 66 for the RSA analysis, and N = 61 for the DES analysis.

A flow chart diagram describing number of participants of the current study who completed the different phases of the study.
Figure 1. Consort diagram of our cross-sectional study. N = 172 participants were screened for eligibility in the study, with 172 meeting initial inclusion/exclusion criteria and approached for consent. N = 141 participants consented to participation (81.9%) with 99 returning for the in-person clinical interview (69.5%). N = 88 (89.8%) participants with usable data necessary for PTSD symptom severity analysis, N = 66 for the RSA analysis, and N = 61 for the DES analysis.

Table 1. Demographic characteristics for overall study sample.

Figure 2. Effects of HIV status and childhood maltreatment on CAPS-5 PTSD symptom severity. HIV was associated with greater PTSD symptoms severity only in women with low levels of childhood maltreatment (p=.030). In women without HIV, high versus low childhood maltreatment was also associated with greater PTSD symptom severity (p<.001).

A bar graph broken down by childhood maltreatment and HIV status that depicts PTSD symptom severity. A bar graph broken down by childhood maltreatment and HIV status that depicts PTSD symptom severity. HIV was associated with greater PTSD symptoms severity only in women with low levels of childhood maltreatment. In women without HIV, high versus low childhood maltreatment was also associated with greater PTSD symptom severity.
Figure 2. Effects of HIV status and childhood maltreatment on CAPS-5 PTSD symptom severity. HIV was associated with greater PTSD symptoms severity only in women with low levels of childhood maltreatment (p=.030). In women without HIV, high versus low childhood maltreatment was also associated with greater PTSD symptom severity (p<.001).

Figure 3. Effects of HIV status and childhood maltreatment on percent potentiation due to darkness during the DES paradigm. Childhood maltreatment was associated with greater percent potentiation to darkness in women living without HIV (p=.018) but not in WLWH (p=.49).

A bar graph broken down by childhood maltreatment and HIV status that depicts percent potentiation due to darkness during the DES paradigm on the y-axis. A bar graph broken down by childhood maltreatment and HIV status that depicts percent potentiation due to darkness during the DES paradigm on the y-axis. Childhood maltreatment was associated with greater percent potentiation to darkness in women living without HIV but not in WLWH.
Figure 3. Effects of HIV status and childhood maltreatment on percent potentiation due to darkness during the DES paradigm. Childhood maltreatment was associated with greater percent potentiation to darkness in women living without HIV (p=.018) but not in WLWH (p=.49).

Figure 4. Effects of HIV status, childhood maltreatment, and phase of DES (light vs. dark) on RSA. RSA was significantly lower during the dark compared to the light phase of the DES task in women without HIV who had experienced low levels of childhood maltreatment (p=.046). WLWH with low childhood maltreatment showed significantly lower RSA during the light phase of the DES compared to women without HIV (p=.042).

A bar graph broken down by light and dark phases, childhood maltreatment and HIV status that respiratory sinus arrythmia (RSA) during the DES paradigm on the y-axis. A bar graph broken down by light and dark phases, childhood maltreatment and HIV status that respiratory sinus arrythmia (RSA) during the DES paradigm on the y-axis. RSA was significantly lower during the dark compared to the light phase of the DES task in women without HIV who had experienced low levels of childhood maltreatment. WLWH with low childhood maltreatment showed significantly lower RSA during the light phase of the DES compared to women without HIV.
Figure 4. Effects of HIV status, childhood maltreatment, and phase of DES (light vs. dark) on RSA. RSA was significantly lower during the dark compared to the light phase of the DES task in women without HIV who had experienced low levels of childhood maltreatment (p=.046). WLWH with low childhood maltreatment showed significantly lower RSA during the light phase of the DES compared to women without HIV (p=.042).

Table 2. Summary of study findings broken down by HIV status (HIV + vs HIV-) and childhood maltreatment (Low vs. High). Significant differences are denoted by comparisons and lack of differences by dashes.