Maternal caffeine intake in pregnancy is inversely related to childhood peer problems in Japan: The Kyushu Okinawa Maternal and Child Health Study

Abstract

Objectives: The present prebirth cohort study examined the association between maternal caffeine consumption during pregnancy and behavioral problems in Japanese children aged 5 years.

Methods: Subjects were 1199 mother–child pairs. Dietary intake was assessed using a diet history questionnaire. Emotional problems, conduct problems, hyperactivity problems, and peer problems were assessed using the Japanese parent-report version of the Strengths and Difficulties Questionnaire. Adjustment was made for maternal age, gestation at baseline, region of residence at baseline, number of children at baseline, maternal and paternal education, household income, maternal depressive symptoms during pregnancy, maternal alcohol intake during pregnancy, maternal smoking during pregnancy, child’s birth weight, child’s sex, breastfeeding duration, and smoking in the household during the first year of life.

Results: The contributors of caffeine in the diet during pregnancy were Japanese and Chinese tea (74.8%), coffee (13.0%), black tea (4.4%), confectionaries (4.0%), and soft drinks (3.7%). Higher maternal caffeine consumption during pregnancy was independently associated with a reduced risk of peer problems in the children: the adjusted odds ratios (95% confidence intervals) in the first, second, third, and fourth quartiles of maternal caffeine consumption during pregnancy were 1 (reference), 0.61 (0.35–1.06), 0.52 (0.29–0.91), and 0.51 (0.28–0.91), respectively (P for trend = 0.01). Maternal caffeine intake during pregnancy was not evidently related to the risk of emotional problems, conduct problems, or hyperactivity problems in the children.

Conclusions: Maternal caffeine consumption, mainly from Japanese and Chinese tea, during pregnancy may be preventive against peer problems in Japanese children.

Keywords:

• Behavioral problems
• Caffeine
• Child
• Maternal intake
• Prebirth cohort

Acknowledgments

The authors would like to acknowledge the Kyushu Branch of the Japan Allergy Foundation, the Fukuoka Association of Obstetricians & Gynecologists, the Okinawa Association of Obstetricians & Gynecologists, the Miyazaki Association of Obstetricians & Gynecologists, the Oita Association of Obstetricians & Gynecologists, the Kumamoto Association of Obstetricians & Gynecologists, the Nagasaki Association of Obstetricians & Gynecologists, the Kagoshima Association of Obstetricians & Gynecologists, the Saga Association of Obstetricians & Gynecologists, the Fukuoka Society of Obstetrics and Gynecology, the Okinawa Society of Obstetrics and Gynecology, the Fukuoka City Government, and the Fukuoka City Medical Association for their valuable support.

Disclaimer statements

Contributors None

Funding This study is supported by JSPS KAKENHI Grant Numbers 19590606JP, 20791654JP, 21590673JP, 22592355JP, 22119507JP, 24390158JP, 25463275JP, 25670305JP, 17K12011JP, and 17H04135JP, by Health and Labour Sciences Research Grants for Research on Allergic Disease and Immunology and Health Research on Children, Youth and Families from the Ministry of Health, Labour and Welfare, Japan, by Meiji Co. Ltd., and by the Food Science Institute Foundation.

Conflict of interest Yoshihiro Miyake and Keiko Tanaka were financially supported by Meiji Co. Ltd. The other authors declare no conflicts of interest.

Ethics approval The ethics committees of Fukuoka University School of Medicine and Ehime University Graduate School of Medicine approved the Kyushu Okinawa Maternal and Child Health Study.

ORCID

Yoshihiro Miyake http://orcid.org/0000-0003-1244-4488

Keiko Tanaka http://orcid.org/0000-0002-3748-5799