Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice

Figures & data

Figure 1. Behavioral deficits in PS19 mice.

Figure 2. Presynaptic changes and neuronal loss in PS19 mice.

Figure 3. Dopamine metabolite levels in PS19 mice.

Figure 4. Phosphorylation of tau in PS19 mice.

Table 1. Phosphorylation of tau in PS19 mice.

(A) Hippocampus
	Ctrl	Trp-Tyr
pTau	162.2 ± 11.8	113.1 ± 17.0 *
tTau	1797.9 ± 326.1	1651.8 ± 296.3
pTau/tTau	0.09 ± 0.01	0.07 ± 0.03
(B) Cortex
	Ctrl	Trp-Tyr
pTau	11.3 ± 1.1	8.5 ± 1.1
tTau	282.6 ± 21.5	317.4 ± 28.8
pTau/tTau	0.04 ± 0.003	0.02 ± 0.003 *

Figure 5. Survival curves in PS19 mice.

Figure 6. Short-chain fatty acid levels in cecum samples of PS19 mice.