Neuraminidase inhibitory terpenes from endophytic Cochliobolus sp.

Abstract

The chemical study of endophytic fungus of Cochliobolus led to the isolation of 10 terpenes (1–10), including one new compound named isocochlioquinone B (1). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 5–7 showed significant neuraminidase inhibitory activity with IC₅₀ values of 0.79–1.75 μM.

Keywords:

• Cochliobolus
• isocochlioquinone
• endophyte
• neuraminidase inhibitor