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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 8
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A new staurosporine analog from Actinomycetes Streptomyces sp. (172614)

Xiao-Bin Li College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China
,
Jin-Shan Tang College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China
,
Hao Gao College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China
,
Rong Ding College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Jia Li Shanghai Institute of Materia Medica, National Center for Drug Screening, Chinese Academy of Sciences, Shanghai, 201203, China
,
Kui Hong Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China
&
Xin-Sheng Yao College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorrespondence[email protected]
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Pages 765-769 | Received 14 Mar 2011, Accepted 04 May 2011, Published online: 13 Jul 2011
 
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Abstract

A new staurosporine analog, 10′-{5″-[(methoxycarbonyl)amino]-2″-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.

Acknowledgements

The authors are grateful to Mr Zhen-Qiang Mu and Miss Yuan-Fan Huang for NMR measurements, Ms Ming-Yan Liu for MS measurements, Mrs Hui-Nan Zhao for HR-ESI-MS measurements. This work was financially supported by grants from the Ministry of Science and Technology of China (2009CB522300, and 2009ZX09302-004), and the Ministry of Education of China/Fok Ying Tung Education Foundation (121039).

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