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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 9
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Original Articles

Identification of the metabolites of baicalein in human plasma

Xiao-Yu Guo Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
,
Lin Yang Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China; Center of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
,
Ying Chen Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
,
Qi-Fang Wang Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Qi-Shi Sun Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Yi-Xin Che Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
&
Qing-Ming Che Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, ChinaCorrespondence[email protected]
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Pages 861-868 | Received 17 Mar 2011, Accepted 19 Jun 2011, Published online: 10 Aug 2011
 
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Abstract

The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1–M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.

Acknowledgements

This research was financially supported by the program of National Natural Science Foundation of China (Grant No. 30225049).

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