Steroidal alkaloids from the bulbs of Fritillaria unibracteata

Abstract

Two new steroidal alkaloids peimisine-3-O-β-d-glucopyranoside (1) and puqiedinone-3-O-β-d-glucopyranoside (3), together with three known compounds peimisine (2), puqiedinone (4), and puqiedine (5), were isolated and characterized from the bulbs of Fritillaria unibracteata. Their structures were fully elucidated by spectroscopic and chemical methods. Compound 1 showed moderate protection effect on neurotoxicity of PC12 cell lines induced by rotenone.

Keywords:

• Fritillaria unibracteata
• steroidal alkaloid
• peimisine-3-O-β-d-glucopyranoside
• puqiedinone-3-O-β-d-glucopyranoside

Acknowledgements

This research program was financially supported by National Science and Technology Project of China (No. 2009ZX09311-004), and the Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education. Our gratitude is extended to Prof. Jin-Feng Hu at the Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College by bioassays.