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Abstract
Two new compounds, penicillone A (1) and penicillactam (2), were isolated together with 17 known compounds from a marine-derived fungus Penicillium sp. F11. The structures of the new compounds as well as a firstly literatural reported known compound (3) were assigned by spectroscopic methods including 1D/2D NMR and MS analysis techniques. Their cytotoxicities against HT1080, Cne2, and Bel7402 cell lines were also evaluated.
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Acknowledgements
The authors would like to acknowledge the financial supports from National Natural Science Foundation of China (No. 81072549) and Projects of International Cooperation of the Ministry of Science and Technology of China (No. 2007AA091904). The project was also supported by the Natural Science Foundation of Fujian Province of China (No. 2010J05087) and Science and Technology Planning Key Project of Fujian Province, China (No. 2009N0040). Thanks to Tian-Hua Zhong of the third Institute of Oceanography for his kind help in determination of NMR spectra.