Two new compounds from the fruits of Buddleja lindleyana with neuroprotective effect

Abstract

Two new triterpenoid glycosides, mimengosides H (1) and I (2), were isolated from the fruits of Buddleja lindleyana Fort. Their structures were determined by extensive spectroscopic methods. Neuroprotective effects of these isolates against 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells were evaluated. Pretreatment with compound 1 had potential protective effect in a concentration range from 0.1 to 1 μmol l^− 1.

Keywords:

• Buddleja lindleyana
• mimengoside H
• mimengoside I
• neuroprotective effect

Acknowledgments

This research was financially supported by the Natural Science Foundation of Education Department of Anhui Province, China (No. KJ2011A185), and by the Natural Science Foundation of Anhui University of Traditional Chinese Medicine (No. 2010zr009B).