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Journal of Asian Natural Products Research Volume 14, 2012 - Issue 5
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Original Articles

Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation

Shu-En Zhang Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Jia-Yi Tao Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Ying Zhao Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Shao-Rong Wang Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Di Zhou Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
&
Wei-Shuo Fang Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
Pages 463-475 | Received 11 Dec 2011, Accepted 29 Feb 2012, Published online: 24 Apr 2012
 
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Abstract

Two new taxoids (5 and 6) were obtained by isolating impurities in aziditaxel, and their structures were characterized based on data analysis of 1H NMR, 13C NMR, HPLC-MS, and through comparison with literature. In order to test their cytotoxicities against human nonsmall lung cancer cell lines (A549), sufficient amounts of compounds 5 and 6 were obtained by semi-synthesis and both of them showed equipotent cytotoxiesty compared with taxol, docetaxel, and aziditaxel.

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