Abstract
Epiberberine, a natural bioactive protoberberine alkaloid, was totally synthesized in short, convenient and low-cost, four-step reactions including cyclization, condensation, reduction, and ring-closing, with an overall yield of 26.1%.
Acknowledgments
We are grateful to the Major Scientific and Technological Specialized Project for Significant New Formulation of New Drugs (2011ZX09401-020) for financial support.