Phenylpropene diglycosides from the bark of Machilus wangchiana

Abstract

Five new phenylpropene diglycosides (1–5), together with three known analogs, have been isolated from an ethanol extract of the bark of Machilus wangchiana. Their structures were determined by spectroscopic and chemical methods. In the preliminary assay, compounds 2 and 5–8 reduced dl-galactosamine (GalN)-induced hepatocyte (WB-F344 cells) damage with 37–41% inhibitions at 10 μM.

Keywords:

• Lauraceae
• Machilus wangchiana
• phenylpropene diglycosides
• hepatocyte protective activity

Acknowledgments

Financial support from the National Natural Sciences Foundation of China (NNSFC; Grant Nos 30825044 and 20932007), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT, Grant No. IRT1007), and the National Science and Technology Project of China (No. 2011ZX09307-002-01) is acknowledged.