Two new compounds from the fungus Penicilliumcrustosum YN-HT-15

Abstract

Our current natural product program researches the second metabolites of a fungus Penicilliumcrustosum YN-HT-15 isolated from the red soil (Yunnan Province, China), to discover potential antitumor chemical entities. Two new compounds were isolated from the ethyl acetate extract of the fermentation broth of the fungus, and their structures were characterized as 1-(2′,4′-dihydroxy-5′-methyl-3′-methylsulfanylmethyl-phenyl)-ethanone (1) and R-3-(3′-acetyl-2′,6′-dihydroxy-5′-methylphenyl)-2-methyl-propionic acid methyl ester (2) on the basis of spectroscopic data.

Keywords::

• fungus
• Penicillium crustosum
• second metabolites
• 1-(2′,4′-dihydroxy-5′-methyl-3′-methylsulfanylmethylphenyl)-ethanone
• R-3-(3′-acetyl-2′,6′-dihydroxy-5′-methylphenyl)-2-methyl-propionic acid methyl ester

Acknowledgements

Supported by Program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University.