A new dipeptide isolated from the bulb of garlic

Abstract

(R)-3-(allylthio)-2-((R)-3-(allylthio)-2-aminopropanamido)propanoic acid was isolated from the bulb of garlic, together with four known amino acids. Its structure was elucidated on the basis of 2D NMR and MS techniques. To the best of our knowledge, (R)-3-(allylthio)-2-((R)-3-(allylthio)-2-aminopropanamido)propanoic acid, which showed antibacterial activity against the Staphylococcus aureus antibiotic resistant strain, was the first example of dipeptide from garlic.

Keywords::

• dipepeptide
• garlic
• antibacterial activity

Acknowledgements

This work was financially supported by the NSFC of China (Nos 31000816, 31101323) and by the high-performance computing platform of Jinan University.