Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 16, 2014 - Issue 4
Submit an article Journal homepage
207
Views
2
CrossRef citations to date
0
Altmetric
Articles

Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells

Rong XuInstitute of Molecular Medicine, Huaqiao University, Quanzhou362021, China;Department of Pharmacy, Quanzhou Medical College, Quanzhou362011, China
,
Mei-Hua JinTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin300070, China
,
Yang JiaoTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin300070, China
,
Guo-Sheng XingOrthopeadic Research Institute of Tianjin Hospital, Tianjin300211, China
,
Wen-Jun ZhaoOrthopeadic Research Institute of Tianjin Hospital, Tianjin300211, China
,
Chuan ZhaoTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin300070, China
,
Hong-Quan DuanTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin300070, ChinaCorrespondence[email protected] [email protected]
&
Sheng-An TangTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin300070, ChinaCorrespondence[email protected] [email protected]
 show all
Pages 351-357 | Received 02 Sep 2013, Accepted 25 Dec 2013, Published online: 20 Jan 2014
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

The gorgonian Echinogorgia sassapo reticulata contains two new bioactive polyhydroxylated steroids, sassapols A (1), B (2), and five related known compounds (3–7). Compound 6 has been encountered for the first time in natural sources. The structures of these new compounds were defined by spectroscopic analysis. All the compounds (1–7) isolated from E. sassapo reticulata were tested for anti-inflammatory activity. Compounds 1, 3, 5, and 7 inhibited both the generation of leukotriene C4 and the degranulation reaction in mouse bone marrow-derived mast cells.

Acknowledgments

This work was partially supported by the National Natural Science Foundation of China (Grant No. 81102371) and the Natural Science Foundation of Tianjin, China (Grant No. 10JCYBJC15000).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.