Three new diterpenoid alkaloids from the roots of Aconitum duclouxii

Abstract

Three new C₁₉-diterpenoid alkaloids, ducloudines C (1), D (2), and E (3), were isolated from the roots of Aconitum duclouxii. Their structures were established on the basis of extensive spectroscopic analyses. Ducloudine C (1) is the first aconitine-type C₁₉-diterpenoid alkaloid with a C = O group at C-3 and a C = C bond between C-1 and C-2. All compounds were tested for their biological activities against one pathogenic fungi and two pathogenic bacteria.

Keywords::

• Aconitum duclouxii
• diterpenoid alkaloids
• biological activity
• ducloudines C–E

Acknowledgments

This work was financially supported by a grant from the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13095), a grant from the Natural Science Foundation of China (No. 21002084) and a grant from the Natural Science Foundation of the Yunnan Province (No. 2010CD017).

Notes

^1. These authors contributed equally to this study.