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A new ursane-type triterpene, cymosic acid from Rosa cymosa

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Pages 422-425 | Received 16 Nov 2013, Accepted 16 Jan 2014, Published online: 06 Mar 2014
 

Abstract

A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its 1H and 13C NMR, 1H–1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.

Acknowledgments

The work was financially supported by National Natural Science Foundation of China (No. 81360683) and the Technological Large Platform for Comprehensive Research and Development of New Drugs in the Twelfth Five-Year ‘Significant New Drugs Created’ Science and Technology Major Projects (No. 2012ZX09301-002-001).

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