New Lycopodium alkaloids from Phlegmariurus squarrosus

Abstract

Four new Lycopodium alkaloids (1–4), together with 15 known ones, were isolated from club moss Phlegmariurus squarrosus. Notably, 8α-hydroxylycojapodine A (1) was the first derivative of lycojapodine A (5) which was a novel C₁₆N-type Lycopodium alkaloid with an unprecedented 6/6/6/7 tetracyclic ring system. Their structures were elucidated based on the spectroscopic data, including 1D and 2D NMR techniques.

Keywords::

• Phlegmariurus squarrosus
• Lycopodium alkaloids
• 8α-hydroxylycojapodine A
• 8β-acetoxy-12β-hydroxy-epidihydrolycopodine
• 8β-acetyllycoposerramine-U
• 11β-acetoxyl-N-methylhuperzine B

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos U0932602 and 90813004) and the National Basic Research Program of China (973 Program Nos 2011CB915503 and 2009CB522303).