Two new sesquiterpenoid glycosides from Nicotiana tabacum

Abstract

Two new sesquiterpenoid glycosides, nicotabalactonecoside (1) and nicotabadiolcoside (2), along with four known terpenoids (3–6) were isolated from the leaves of Nicotiana tabacum. The structures of compounds 1 and 2 were determined as dihydrodeacetylphytuberin-2-one 11-O-β-d-glucopyranoside and 1,2-dehydro-4-epieremophil-9-ene-11,12-diol 12-O-β-d-glucopyranoside by extensive spectroscopic analyses (HR-ESI-MS, UV, IR, 1D, and 2D NMR) and chemical method. Compound 1 is an unusual phytuberin-type sesquiterpenoid with a 6/5/5 tricyclic system.

Keywords::

• nicotabalactonecoside
• nicotabadiolcoside
• sesquiterpenoids; Nicotiana tabacum

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China for Distinguished Young Scholars (No. 81025023) and the Youth Innovation Promotion Association, CAS.