Coniothyren: a new phenoxyphenyl ether from the endophytic fungus, Coniothyrium sp.

Abstract

Phytochemical investigation of the endophytic fungus Coniothyrium sp. resulted in the isolation of a new phenoxyphenyl ether, named coniothyren (1), and two known compounds, coniol (2) and (+)-epoxydon (3). The structure of the new compound was elucidated by detailed spectroscopic analysis, namely, ¹H NMR, ¹³C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Preliminary studies demonstrated that (+)-epoxydon (3) displayed good antibacterial and antialgal activities toward Bacillus megaterium and Chlorella fusca, respectively.

Keywords::

• natural product
• endophytic fungi
• Coniothyrium sp

Acknowledgments

The authors thank BASF AG and the BMBF (Bundesministerium für Bildung und Forschung, project no. 03F0360A).