New cyclopeptide alkaloid and lignan glycoside from Justicia procumbens

Abstract

This study reported a new cyclopeptide alkaloid, justicianene A (1), and a new lignan glycoside, procumbenoside H (2), isolated from Justicia procumbens. The structures of the new compounds were elucidated by means of spectroscopic analysis, including extensive 2D NMR studies and mass spectrometry. Cyclopeptide alkaloids were first observed from the genus Justicia. Compound 2 was cytotoxic against human LoVo colon carcinoma cells with an IC₅₀ value of 17.908 ± 1.949 μM.

Keywords::

• Justicia procumbens
• cyclopeptide alkaloid
• lignan glycoside
• cytotoxic

Acknowledgments

The authors thank Mrs Yan Xue, Mrs Mei-feng Xu, and Mrs Yu-mei Zhao of the National Center of Biomedical Analysis for the measurements of the HR-ESI-MS and NMR spectra.