Novel polyacetylenes from Coreopsis tinctoria Nutt.

Abstract

Phytochemical investigation of the 95% EtOH extract of Coreopsis tinctoria Nutt. resulted in the isolation of two novel polyacetylenes, (2S)-(3Z,11E)-decadiene-5,7,9-triyne-1,2-diol (1) and (2R)-(3E,11Z)-decadiene-5,7,9-triyne-1,2-diol (2), together with two known polyacetylenes (3 and 4). The structures of these novel compounds were determined by extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. Compounds 1, 2, and 4 were evaluated for their anti-proliferative activities against C26 cell growth and inhibitory effects on the lipo-poly-saccharides-induced nitric oxide production using murine macrophage RAW 264.7 cells. However, compounds 1, 2, and 4 just showed weak activities.

Keywords::

• Coreopsis tinctoria
• polyacetylene
• structure elucidation
• anti-proliferation
• anti-inflammation

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

^1. Two authors contributed equally to this work.

Additional information

Funding

This work was financially supported by the grants from China Postdoctoral Science Foundation [No. 2013M530402], the China National ‘12.5’ Foundation [No. 2011BAJ07B04], and Open Foundations [SKLODSCUKF2012-03] from the State Key Laboratory of Oral Diseases Sichuan University.