Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats

Abstract

Quercetin, a flavonoid present in many plants, is reported to be effective in models of neurodegenerative diseases. The aim of the present study was to evaluate the anti-tremor effects of quercetin in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. In rats, quercetin had no effect on apomorphine-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA lesioned rats. Interestingly, quercetin could decrease the burst frequency in a dose- and time-dependent manner. These results suggest that quercetin may have a protective effect on models to mimic muscle tremors of Parkinson's disease. This effect of quercetin may be associated with serotonergic system, but further study is needed.

Keywords::

• Parkinson's disease
• quercetin
• tremor
• 6-hydroxydopamine

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

^1. Both contributed equally to this work.

Additional information

Funding

This work was financially supported by National Science and Technology Major Project [grant number 2013ZX09102106].